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The De Wulf lab at the Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Italy, is looking for an outstanding, highly motivated post-doctoral scientist to study the activity of a conserved oncogenic kinase in the budding yeast Saccharomyces cerevisiae. The research project wishes to understand how this kinase regulates (peri)centromeric chromatin and telomeres to ensure timely kinetochore assembly, chromosome transmission, and cellular aging.
Candidates with expertise in genetics, biochemistry, cellular and molecular biology are highly encouraged to apply. Knowledge of yeast (S. cerevisiae or other) and cell cycle biology is not essential but is a bonus. Experience with live-cell fluorescence imaging is appreciated. The candidate should hold a recent Ph.D. degree and a good publication record (at least one first-author publication in a reputable peer-reviewed journal). S/he must be motivated to excel in science, be curious, creative, open-minded, and pro-active. The University of Trento (https://www.unitn.it/) is top-ranked in Italy, and our department (comprising 46 labs, https://www.cibio.unitn.it/) ranks first in the Biological Sciences.
Candidates are thought for several post-doc and PhD positions to work on structural and functional characterisation of large membrane protein complexes, funded by the recently awarded ERC Advanced grant.
The group of Professor Leonid Sazanov is interested in the structures and mechanisms of large molecular machines, especially redox proteins relevant to bioenergetics of mitochondria and bacteria, such as components of the respiratory chain. We have published our findings in many articles in Nature and Science.
We are now interested in determining the intriguing coupling mechanism of complex I using the latest methods in high-resolution cryo-EM single particle analysis, especially time-resolved studies. We are also interested in further extending our structural studies to other related enzymes, both in the respiratory chain and elsewhere.
Applicants with PhD and experience in protein purification and characterization, or in structural biology methods are encouraged to apply for post-doc positions. Applicants for PhD positions should be recent graduates from top universities with degrees in biochemistry/biophysics.
We are based in the Institute of Science and Technology in Austria, near Vienna. IST Austria is a new institute dedicated to basic research, providing world-class research environment and benefits. Among its EM facilities, IST has top-range Krios and Glacios TEMs, as well as FEI Vitrobot IV, suitable for optimization of sample preparation.
Description: We are seeking candidates for a Postdoc, Student, or Visiting Scientist position in the laboratory of Dr. Anna Vilgelm in the Department of Pathology at the Ohio State University in Columbus, Ohio. Our main area of research is tumor immunology. The successful candidate will work to characterize the mechanisms of tumor immune escape associated with modulation of immune cell recruitment and retention in the tumor microenvironment. To this end, the candidate will develop, adopt and implement cutting-edge laboratory methods, including multi-omics, automated microscopy, spectral cytometry, CRISPR editing, and complex Patient-Derived cultures. Projects will require working in close collaboration with clinical oncologists and data scientists to ensure impactful translational discoveries. Vilgelm laboratory is affiliated with the Center for Cancer Engineering, Translational Therapeutics Program, and the Pelotonia Institute for ImmunoOncology. https://pathology.osu.edu/faculty/vilgelm.html Columbus is a hub for nature lovers, history buffs, sports fans, and animal lovers. It is the state capital of Ohio with beautiful recreational parks, low cost of living, mild climate, and a vibrant research environment.
Requirements: We are seeking highly motivated individuals interested in pursuing a career in biomedical sciences. Applicants for a postdoctoral scholar position should have a recent Doctoral degree in Immunology, Cancer Biology, Bioinformatics, or closely related fields. Prior experience in flow cytometry, omics data analysis, cell culture, and/or mouse models is desired. Fluency in English (written and communication skills) is required. To apply, please email your CV including the contact information of three references and a brief description of research experience and interests to Anna Vilgelm using the link below.
What you will do • Biostatistical analysis of data sets using e.g., Machine Learning, Regression analysis, ANOVA, Mixed models, Bayesian analysis etc. • Programming with at least one of the following SW packages: R/Python/SAS. More than one is a big plus • Formulation of biologically relevant conclusions in cooperation with biologists • Independent processing of assigned tasks • Assistance in the development of Methods and applications
Prospective candidates should fulfil the following criteria • PhD degree (preferably in Biostatistics) • Motivation and interest in cutting-edge science • Good communication and interpersonal skills • Fluent English– spoken and written
Desirable but not required • Motivated person with a collaborative mind set • Willingness to actively engage with the wider academic community
Start date: as soon as possible
Application including CV, short motivation letter including a description of previous research background/interests and contacts for at least two referees should be sent by e-application available here.
Or you can contact Markéta Pernisová (marketa.pernisova@ceitec.muni.cz).
In case you need any help with filling the e-application, please contact Lucie Janštová on lucie.janstova@ceitec.muni.cz Electronic application deadline is 7 January 2021. Shortlisted candidates will be invited for interview by the Recruitment Committee.
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Postdoctoral position, Ovarian Cancer and Necroptosis, The Hormel Institute, University of Minnesota, USA Postdoctoral position A Postdoctoral position for an extremely motivated researcher to study the role of molecular and metabolic aspects of cell programmed necrosis (necroptosis) in Ovarian Cancer Stem cells is available at Hormel Cancer Research Institute, University of Minnesota in Austin, MN in the Laboratory of Dr. Ilana Chefetz. Our lab aims to expand our understanding of necroptosis and energy metabolism and provide critical pre-clinical studies for a potential novel Cancer Stem cells targeted therapeutics to prevent recurrent ovarian cancer. Applicants should have a PhD degree in molecular and cellular biology or biomedical sciences and experience in mice handling (or willing to learn). Experience in cancer biology, Cancer Stem Cells, MSC/iPSC, cell death pathways, FACS, metabolism, Genetically Engineered mice model, RNA-seq and cloning is desirable. Applicants should have ability to develop new and improved methodology. Good communication and organizational skills, and good knowledge of English (both verbal and written) are required. Applicants should have demonstrated scientific productivity, have a strong publication record, be able to design and execute scientific experiments independently, write manuscripts, prepare and submit competitive fellowship applications. Please send a CV, Cover Letter explaining relevant work experience, and contact information for 3-5 Referees to: Ilana Chefetz, PhD, Assistant Professor, The Hormel Institute, University of Minnesota. ichefetz@umn.edu https://med.umn.edu/bio/stem-cell-faculty-b...chefetz-menaker
A postdoctoral position is available at the Emory University School of Medicine to join an innovative laboratory that studies the mechanism of virus entry into cells and its regulation by host factors. Our group combines molecular/cell biology, biochemistry and quantitative microscopy techniques, such as single particle tracking and super-resolution imaging, to investigate the early steps of infection – membrane fusion, transport and uncoating of viral core. To gain structural insights into virus entry intermediates, we are implementing correlative light-cryo-electron microscopy (cryo-CLEM) techniques. A candidate will work with a collaborative interdisciplinary team and an enthusiastic mentor. Highly motivated individuals holding a Ph.D. degree in virology, cell biology, biophysics or related fields are encouraged to apply. Emory University provides excellent training and collaborative environment for research. For more information regarding projects in the laboratory, please visit: http://www.pedsresearch.org/research-group/melikian-lab and http://www.pediatrics.emory.edu/divisions/...kian/index.html. Interested applicants should contact Dr. Gregory Melikian (aka Melikyan) at gmeliki@emory.edu.
A postdoctoral position is available in the Lobanova Laboratory with the Department of Ophthalmology at the University of Florida. The laboratory studies pathogenic changes in lipid metabolism and protein degradation in retinal diseases with the aim of identifying and validating new therapeutic strategies with high translational potential.
Qualifications Applicants should have a recent Ph.D. degree in biological sciences/biophysics/ biochemistry/molecular biology with a track record of working on complex problems and high-quality publication(s). The applicant’s training should provide sufficient preparation to use mouse models of retinal degeneration, AAV-based gene delivery systems, cell culture, metabolomics and genomics approaches (RNA-seq, Chip-seq, single-cell RNA-seq) to identify pathways implicated in retinal pathogenesis and to develop and validate new therapeutic strategies. Ideal candidates are dynamic and self-motivated individuals that can take ownership of the projects and work in a fast-paced multidisciplinary environment.
Qualified candidates should submit a cover letter describing an interest in the position and relevant experience, curriculum vitae, research statement and contact information for the three references. If preferred, reference letters can be addressed to Ekaterina Lobanova, Ph.D., Assistant Professor, Department of Ophthalmology or apply here.
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Responsible for performing in vitro and in vivo experiments using molecular, biochemical and cellular assays in cell culture systems and animal models. Define goals for research projects and experiments in conjunction with PI and other research staff.
Manage mouse colony database, including genotyping, and record experiments. Analyze tissues from rodents by Western blotting techniques, process tissue for microscopic examination.
Operate diagnostic laboratory equipment, including (but not limited to) electroretinogram (ERG), digital fundus camera, optical coherence tomography (OCT) microscopes, and real-time PCR. Collecting. Transform data obtained from the equipment listed above for research staff, including familiarizing oneself with the computer based data acquisition software as needed.
EXPECTED SALARY: $16.18 - $21.02 per hour
MINIMUM REQUIREMENTS: BS, MS or PhD in biology or a closely related life science field.
PREFERRED QUALIFICATIONS: The ideal candidate should have experience in protein biochemistry assays, maintaining cell lines, production of lentiviral vectors, performing plasmid transfections/viral infections, immunohistochemistry, real time-PCR and genotyping. Possess the ability to work efficiently as part of a productive team and have a strong work ethic. Preference will be given to applicants that have demonstrated the ability to work as part of a collaborative team and have a strong interest in translational research. Good communication skills are essential. Experience characterizing retinal function and structure in rodent models (ERG, OCT, fundoscopy, behavior testing), gene therapy and/or virology are preferred.
SPECIAL INSTRUCTIONS TO APPLICANTS: In order to be considered, you must upload a cover letter, resume, and list of references.
The Kondrashov lab is looking for an experienced molecular and/or synthetic biologist to spearhead a series of experiments focusing on the study of the genotype to phenotype map (fitness landscape). The main directions of research include the study of deep mutational scans and other synthetic libraries probing the fitness landscapes of proteins and more complex genotypes. Development of the scientist’s own research direction is encouraged and training and supervision of molecular work of junior scientists and students is expected. The position is in Okinawa, Japan, salary competitive and negotiable, long-term contracts available, starting date from January 2022. Applicants should send their CV and statement of purpose to Fyodor Kondrashov (fkondrashov@gmail.com). Please include a brief description of a fitness landscape or synthetic biology project you may wish to undertake independently and why you may want to do it.
The Kondrashov lab is looking for an experienced bioinformatician to spearhead genomic and bioinformatic analysis for a range of projects in the lab. The main directions of research include assembly and annotation of non-model organism genomes and work with sequencing of DNA libraries from experiments of deep mutational scans. Development of the scientist’s own research direction is encouraged and training and supervision of bioinformatic work of junior scientists and students is expected. The position is in Okinawa, Japan, salary competitive and negotiable, long-term contracts available, starting date from January 2022. Applicants should send their CV and statement of purpose to Fyodor Kondrashov (fkondrashov@gmail.com). Please include a brief description of a genome sequencing project you may wish to undertake as your own project and why you may want to do it.
We have exciting projects on the potential of many human genes to be dual-coding (two overlapping open reading frames) or bicistronic (two non-overlapping open reading frames). Discover the true coding potential of our genome, study the structure/function of novel proteins, invent new tech. We use bioinformatics, proteomics, biochemistry and cell biology techniques. One (but not the only) of the novel proteins, alternative FUS, is co-expressed with the canonical FUS protein from the dual-coding FUS gene. altFUS coding sequence overlaps the FUS coding sequence in an alternative open reading frame. AltFUS is endogenously expressed in the human brain and other tissues, and both FUS and altFUS are involved in the aetiology of amyotrophic lateral sclerosis and its pathological hallmarks (PMID: 33226175). In this project, we are particularly interested in elucidating how altFUS prevents the recruitment of the PARKIN E3 ubiquitin ligase to the mitochondria during mitophagy. We also investigate large-scale protein-protein interactions and functionally annotate several thousands novel proteins in several species (PMID: 33179748). If potentially interested, email me xavier.roucou@usherbrooke.ca
A postdoctoral position is available (2021) in mitochondrial research lab of Dr Alexander Galkin at Columbia University, an Ivy League research university ranked #3 in the USA. Selected candidate will have the opportunity to benefit from the unique career and mentoring support available in Columbia Medical Center.
The postdoc will be involved in an NIH-funded project focused on understanding the role of mitochondrial and metabolic impairments during brain ischemia/reperfusion using in vivo animal models.
We are seeking a highly motivated, enthusiastic and autonomous postdoctoral researcher with laboratory experience related to enzyme activity measurements, cellular fractionation, metabolomics data acquisition and analysis, able to work independently and with others. A background in mitochondrial biology and experience with preparative techniques are assets but not requirements. Applicant should have a PhD or an equivalent. Please include the following with your applications:
1. Your curriculum vitae 2. A brief (1/2 page) statement of research interests and accomplishments and career plans 3. One representative manuscript (published or submitted) 4. Contact details of three referees.
To apply please contact Alexander Galkin (ag4003@cumc.columbia.edu). Selected applicants will be invited to an interview via Skype/Zoom.
• Ten V and Galkin A. (2019) Mechanism of mitochondrial complex I damage in brain ischemia/reperfusion injury. A hypothesis. Mol Cell Neurosci. 100, 103408. PMID: 31494262 • Stepanova et al., (2019) Redox-Dependent Loss of Flavin by Mitochondrial Complex I in Brain Ischemia/Reperfusion Injury. Antioxid Redox Signal. 31, 608-622. PMID:31037949
Laboratory of Trypanosomatid Biology, University of Ostrava, Czech Republic invites enthusiastic highly motivated students with a strong background in molecular biology or biochemistry to apply for two PhD positions starting from September, 2021. The projects will address the role of host factors governing dsRNA viral maintenance in Leishmania guyanensis and RNA editing in non-model trypanosomatids.
Requirement: fluent English, advanced molecular biology skills (DNA, RNA, protein analyses, genome manipulations). Basic bio-computing experience (e.g. genome and transcriptome analysis) is advantageous.
Recent publication: 1. Gerasimov et al, 2021 Nucl. Acids Res. doi:10.1093/nar/gkab114 2. Gerasimov et al, 2018 Nucl. Acids Res. doi:10.1093/nar/gkx1202 3. Grybchuk et al, 2018 Proc. Natl. Acad. Sci. USA doi:10.1073/pnas.1717806115
Laboratory of Trypanosomatid Biology is well equipped and provides excellent conditions for research. The successful candidate will work in an international team of friendly and talented people. For more information visit the lab web page at http://web.osu.cz/~yurchenko/
How to apply: Please send your Resume, Motivation letter, names and contact information of potential referees to Prof. Vyacheslav Yurchenko, Ph.D. by April 15th, 2021. E-mail: vyacheslav.yurchenko@osu.cz
The Molecular BioEngineering group (https://www.piatkevich-lab.com/) in the School of Life Sciences at Westlake University, China, is seeking research associates at the level of postdoctoral fellows. The research associates will work collaboratively within a multi-disciplinary research team aimed at developing and validating new molecular technologies for brain interfacing. The ideal applicant should have extensive experience in electrophysiology, in vivo imaging, neuroscience, microscopy, protein engineering. cell biology, chemical synthesis, optics. The scope of the research projects involves i) the development of genetically encoded biosensors of neuronal activity; ii) non-invasive methods for controlling neuronal activity with high spatiotemporal resolution in vivo; iii) novel methods for optical connectomics; iv) elucidating the pathogenic mechanisms underlying neurological disorders. The internationally competitive salary and benefits (including social insurance, medical insurance, etc.) are provided. Westlake University (https://en.westlake.edu.cn/) provides a first-class research environment and infrastructure. Opportunities exist for personal career development. Westlake University is a first private research-oriented university located in Xihu District, Hangzhou, Zhejiang Province in China organized by China's social forces and supported by the private donations. Working at Westlake University offers opportunities, an environment, a culture - and benefits - that just aren't found together anywhere else.
Apply by email to Dr. Kiryl Piatkevich (kiryl.piatkevich@westlake.edu.cn) providing the following information:
1. A brief statement describing your projects, career goals, and research interests;
2. An up-to-date CV detailing education, research experience, skills, and publications;
3. Names and emails of three references who can provide letters of recommendation.
The Verkhusha laboratory at the Albert Einstein College of Medicine https://www.einstein.yu.edu/faculty/10316/v...slav-verkhusha/ is looking for two postdocs interested in the development and applications of biosensors and optogenetic tools for monitoring and control of biological processes in cells and animals. We are a protein engineering laboratory with the emphasis on neuroscience. Current projects focus on engineering of fluorescent protein-based biosensors for imaging of neuromodulators, neurotransmitters, enzyme activities, coupled with optogenetics. They involve all steps of tool development and validation including fluorescence imaging in cultured neurons and, later, in mice to correlate specific behavior, sensation and cognitive processes to neuronal activity in the brain. More details on the laboratory projects can be found in recently published papers: https://pubmed.ncbi.nlm.nih.gov/?term=verkh...a&sort=pubdate/ We have two open positions. One position is for a molecular biologist willing to engineer fluorescent protein-based biosensors and characterize them in vitro and in cultured cells. Another position is for a neuroscientist willing to couple imaging with advanced biosensors to optogenetic control of activity and molecular processes in neurons, using cellular electrophysiology, electric field stimulation, optogenetics and calcium imaging. The initial salary is $4400 per month. To apply, please, email your CV to postdoc.einstein@gmail.com The Albert Einstein College of Medicine offers a highly interactive and stimulating academic environment for scientists who also benefit from the programs in Biophotonics Center, Innovation Imaging laboratory, Department of Neuroscience and throughout the College. Einstein is located in a pleasant residential area in the northeast corner of New York City with an easy commute to downtown Manhattan. The College offers medical insurance and subsidized apartment in the postdoctoral housing.